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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8182 | Guanfu base A | Guan-fu base A | P450 , Potassium Channel , HER |
Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current. | |||
T8182L | Guan-fu base A hydrochloride(1394-48-5 free base) | P450 | |
Guan-fu base A hydrochloride is an antiarrhythmic alkaloid was isolated from Aconitum coreanum. Guanfu base A is hydrochloride a CYP2D6 inhibitor of human, monkey, and dog isoforms. | |||
T11510 | Guanfu base I | Acorine | Others |
Guanfu base I is an active metabolite of Guanfu base A, isolated from Aconitum coreanum. It have a potent anti-arrhythmic effect. | |||
T11509 | Guanfu base H | Atisinium chloride | Others |
Guanfu base H is a diterpenoid alkaloid isolated from Aconitum coreanum. It has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 (IC50s: 4 μM and 3.6 μM). |